Bioprinter portátil trata queimaduras graves 'imprimindo' novas células directamente na ferida

Uma equipa de pesquisadores no Canadá testou com sucesso uma nova impressora 3D portátil de pele, que trata queimaduras graves 'imprimindo' novas células directamente na ferida.


A equipa de pesquisa projectou um dispositivo portátil para depositar folhas precursoras directamente em feridas de qualquer tamanho, forma ou topografia. Ele usa um bioink baseado em fibrina - uma proteína envolvida na coagulação do sangue - infundida com células que apoiam o crescimento das células locais e auxiliam na resposta do sistema imunitário. Isso é 'impresso' directamente na ferida pelo rolo macio do dispositivo.

In general, the wound surfaces we designed this device for are not flat, nor are they oriented horizontally. One of the most important advantages of the device is that it should allow for the uniform deposition of a bioink layer onto inclined surfaces.

In this study, we tested whether the device could do this effectively by using it to treat full-thickness burns in pigs. We found the device successfully deposited the ‘skin sheets’ onto the wounds uniformly, safely and reliably, and the sheets stayed in place with only very minimal movement.

Most significantly, our results showed that the MSC-treated wounds healed extremely well, with a reduction in inflammation, scarring, and contraction compared with both the untreated wounds and those treated with a collagen scaffold.

~Dr. Marc Jeschke, co-autor e director médico do Ross Tilley Burn Center no Sunnybrook Health Sciences Center em Toronto

We’re extremely pleased by this successful test. As well as the excellent healing outcomes, we’ve shown that the device offers a user-friendly method for safe cell and biomaterial delivery. Further study is required, but the signs are promising and the potential clinical applications for the device extend well beyond full thickness burn injuries.

~Professor Axel Günther, autor sénior da Universidade de Toronto



fonte: SciTechDaily

Licença CC BY-SA 4.0 Silvia Pinhão Lopes, 10.3.20